In the Action dropdown, select Send Hex Code.Add a global shortcut key, and just type in your shortcut.Open the preferences (⌘+,) and go to the Keys tab.The following is what I've found to work on my machine. By default, iTerm2 isn't configured this way, and there are a lot of misleading guides online.
⌘+ ← and ⌘+ → are for going to the beginning and end of lines.
In OSX, ⌥+⌫ and ⌘+⌫ are the shortcuts for deleting a word and deleting a line respectively.